THE EFFECT OF 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN ON THE SIMULTANEOUS DISSOLUTION AND DEGRADATION OF CHLORAMBUCIL

被引：5
|
作者：
LOFTSSON, T
OLAFSDOTTIR, BJ
机构：
[1] Department of Pharmacy, University of Iceland, Reykjavik
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1990年 / 66卷 / 1-3期
关键词：
CHLORAMBUCIL; DISSOLUTION; DEGRADATION; CYCLODEXTRIN;
D O I：
10.1016/0378-5173(90)90410-6
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of 2-hydroxypropyl-beta-cyclodextrin (2-HPCD) on the simultaneous dissolution and degradation of chlorambucil from rotating compressed disks in aqueous buffer solutions was investigated. The compressed disks consisted of chlorambucil-2-HPCD complex or physical mixtures of chlorambucil and 2-HPCD, D-(+)-glucose or microcrystalline cellulose. The stabilizing and solubilizing effects of 2-HPCD on the chlorambucil molecule significantly improves the dissolution characteristics of the drug in aqueous media. The fastest rate of dissolution was obtained from disks containing chlorambucil-2-HPCD complex.
引用
收藏
页码：289 / 292
页数：4
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