STUDIES ON SEMIRIGID TRICYCLIC ANALOGS OF THE NIGROSTRIATAL TOXIN 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE

被引:25
作者
BOOTH, RG
TREVOR, A
SINGER, TP
CASTAGNOLI, N
机构
[1] UNIV CALIF SAN FRANCISCO,SCH PHARM,DEPT PHARM,SAN FRANCISCO,CA 94143
[2] UNIV CALIF SAN FRANCISCO,SCH PHARM,DEPT PHARMACEUT CHEM,SAN FRANCISCO,CA 94143
[3] UNIV CALIF SAN FRANCISCO,SCH MED,DEPT PHARMACOL,SAN FRANCISCO,CA 94143
关键词
D O I
10.1021/jm00122a031
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
引用
收藏
页码:473 / 477
页数:5
相关论文
共 42 条
[1]   ETIOLOGY OF PARKINSONS-DISEASE - A RESEARCH STRATEGY [J].
BARBEAU, A .
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1984, 11 (01) :24-28
[2]   IDENTIFICATION AND QUANTIFICATION OF 1,2,3,4-TETRAHYDRO-BETA-CARBOLINE, 2-METHYL-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE, AND 6-METHOXY-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE AS INVIVO CONSTITUENTS OF RAT-BRAIN AND ADRENAL-GLAND [J].
BARKER, SA ;
HARRISON, REW ;
MONTI, JA ;
BROWN, GB ;
CHRISTIAN, ST .
BIOCHEMICAL PHARMACOLOGY, 1981, 30 (01) :9-17
[3]  
BROSSI A, 1986, J MED CHEM, V29, P445
[4]   A PRIMATE MODEL OF PARKINSONISM - SELECTIVE DESTRUCTION OF DOPAMINERGIC-NEURONS IN THE PARS COMPACTA OF THE SUBSTANTIA NIGRA BY N-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE [J].
BURNS, RS ;
CHIUEH, CC ;
MARKEY, SP ;
EBERT, MH ;
JACOBOWITZ, DM ;
KOPIN, IJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (14) :4546-4550
[5]   METABOLISM OF THE NEUROTOXIC TERTIARY AMINE, MPTP, BY BRAIN MONOAMINE-OXIDASE [J].
CHIBA, K ;
TREVOR, A ;
CASTAGNOLI, N .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 120 (02) :574-578
[6]  
CHIBA K, 1985, DRUG METAB DISPOS, V13, P342
[7]   ACTIVE UPTAKE OF MPP+, A METABOLITE OF MPTP, BY BRAIN SYNAPTOSOMES [J].
CHIBA, K ;
TREVOR, AJ ;
CASTAGNOLI, N .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1985, 128 (03) :1228-1232
[8]   BETA-CARBOLINE ANALOGS OF N-METHYL-4-PHENYL-1,2,5,6-TETRA-HYDROPYRIDINE (MPTP) - ENDOGENOUS FACTORS UNDERLYING IDIOPATHIC PARKINSONISM [J].
COLLINS, MA ;
NEAFSEY, EJ .
NEUROSCIENCE LETTERS, 1985, 55 (02) :179-184
[9]   CHRONIC PARKINSONISM SECONDARY TO INTRAVENOUS-INJECTION OF MEPERIDINE ANALOGS [J].
DAVIS, GC ;
WILLIAMS, AC ;
MARKEY, SP ;
EBERT, MH ;
CAINE, ED ;
REICHERT, CM ;
KOPIN, IJ .
PSYCHIATRY RESEARCH, 1979, 1 (03) :249-254