SCATTER FACTOR FROM HUMAN EMBRYONIC LUNG FIBROBLASTS IS PROBABLY IDENTICAL TO HEPATOCYTE GROWTH-FACTOR

被引：82
作者：
KONISHI, T
TAKEHARA, T
TSUJI, T
OHSATO, K
MATSUMOTO, K
NAKAMURA, T
机构：
[1] KYUSHU UNIV,FAC SCI,DEPT BIOL,FUKUOKA 812,JAPAN
[2] UNIV OCCUPAT & ENVIRONM HLTH,SCH MED,DEPT SURG 1,KITAKYUSHU,FUKUOKA 807,JAPAN
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1991年 / 180卷 / 02期
关键词：
D O I：
10.1016/S0006-291X(05)81131-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Human embryonic lung fibroblasts (MRC5) produced scatter factor which enhanced motility of Madin-Darby canine kidney (MDCK) epithelial cells and a factor which stimulates DNA synthesis of adult rat hepatocytes in primary culture. These activities were both completely neutralized by antibody against human hepatocyte growth factor (HGF). Human recombinant HGF induced a marked scattering of MDCK cells. Moreover, MRC5 cells highly expressed 6kb mRNA which hybridized with HGF cDNA probe and scatter factor cDNA cloned from the MRC5 cDNA library had the same sequence as that of HGF cDNA from human leukocytes. These results indicate that HGF possesses scatter factor activity and the scatter factor derived from the MRC5 cells is probably identical to HGF. © 1991 Academic Press, Inc.
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页码：765 / 773
页数：9
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