PROTEIN-KINASE-C INCREASE IN RAT-BRAIN CORTICAL MEMBRANES MAY BE PROMOTED BY COGNITION ENHANCING DRUGS

被引：16

作者：

GOVONI, S

LUCCHI, L

BATTAINI, F

TRABUCCHI, M

机构：

[1] UNIV MILAN, INST PHARMACEUT SCI, VIA BALZARETTI 9, I-20133 MILAN, ITALY

[2] UNIV BARI, DEPT PHARMACOBIOL, I-70125 BARI, ITALY

[3] UNIV ROME 2, DEPT EXPTL MED & BIOCHEM SCI, I-00173 ROME, ITALY

来源：

LIFE SCIENCES | 1992年 / 50卷 / 16期

关键词：

D O I：

10.1016/0024-3205(92)90465-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Protein Kinase C (PKC) activity was measured in soluble and particulate fractions of rat individual brain cortices after in vivo treatment with two cognition enhancers: oxiracetam and alpha-glycerylphosphorylcholine. Both drugs induced an increase (+40-50%) of PKC particulate activity at 1 hr after the treatment. The effect was transient; at 5 hours PKC activity was lower than in controls. The dose response curve to oxiracetam was bell shaped, the increase of PKC being significant at 100 mg/Kg. At higher doses the drug induced a decrease in enzyme activity. The increased PKC activity may be related to the cortical effects of these compounds.

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收藏

页码：PL125 / PL128

页数：4

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