CALCIUM IS AN INTRACELLULAR MEDIATOR OF THE CLIMBING FIBER IN INDUCTION OF CEREBELLAR LONG-TERM DEPRESSION

被引：197

作者：

SAKURAI, M ^{[1
]}

机构：

[1] UNIV TOKYO,FAC MED,DEPT PHYSIOL,TOKYO 113,JAPAN

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 09期

关键词：

D O I：

10.1073/pnas.87.9.3383

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In cerebellar Purkinje cells, conjunctive stimulation of parallel fibers and the climbing fiber causes long-term depression of parallel fiber-Purkinje cell transmission. It has been postulated that calcium is an intracellular mediator of the climbing fiber to induce this synaptic modification. To directly test the hypothesis, a calcium-chelating agent, EGTA, was intracellularly injected into Purkinje cells. In these injected cells, conjunctive stimulation failed to induce depression. Instead, it caused potentiation similar to that observed after repetitive stimulation of parallel fibers alone.

引用

页码：3383 / 3385

页数：3

共 21 条

[1] INTRACELLULAR CA2+ ACTIVATES A FAST VOLTAGE-SENSITIVE K+ CURRENT IN VERTEBRATE SYMPATHETIC NEURONS [J].