SHORT, TERMINALLY PHOSPHORYLATED OLIGORIBOGUANYLIC ACIDS EFFECTIVELY INHIBIT CYTOPATHICITY CAUSED BY HUMAN-IMMUNODEFICIENCY-VIRUS

被引：12

作者：

FUJIHASHI, T

SAKATA, T

KAJI, A

KAJI, H

机构：

[1] THOMAS JEFFERSON UNIV, JEFFERSON MED COLL, DEPT PHARMACOL, PHILADELPHIA, PA 19107 USA

[2] UNIV PENN, SCH MED, DEPT MICROBIOL, PHILADELPHIA, PA 19104 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 203卷 / 02期

关键词：

D O I：

10.1006/bbrc.1994.2316

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Various synthetic ribonucleic acids were evaluated for inhibition of HIV-induced cytopathicity of cultured cells; only poly and oligoguanylic acids, but not other homopolymers, showed potent inhibitory activity. Phosphorylation of either the 5'- or 3'-end of oligoribonucleotides converted short inactive oligomers, such as dimers to effective anti-HIV agents. The efficacy of the 3'-phosphorylated phosphorothioate trimer of guanylic acid was comparable to that of other longer oligonucleotides so far reported. Phosphorothioate oligoriboguanylic acids were superior to the corresponding oligodeoxyguanylic acids in their capacity to prevent HIV cytopathicity. (C) 1994 Academic Press, Inc.

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页码：1244 / 1250

页数：7

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