ANTIINFLAMMATORY AND HEPATOPROTECTIVE EFFECTS OF VENTILAGO-LEIOCARPA

被引:20
作者
LIN, CC
LIN, WC
CHANG, CH
NAMBA, T
机构
[1] CHIA NAN JR COLL PHARM,DEPT PHARM,TAINAN,TAIWAN
[2] TOYAMA MED & PHARMACEUT UNIV,WAKAN YAKU RES INST,SUGITANI,TOYAMA 93001,JAPAN
关键词
CARRAGEENAN; CCL4; ANTIINFLAMMATORY; HEPATOPROTECTIVE; VENTILAGO LEIOCARPA;
D O I
10.1002/ptr.2650090104
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Two animal experiments models including carrageenin-induced oedema and CCl4-induced liver injury were investigated to compare and elucidate antiinflammatory and hepatoprotective effects of four fractions (CHCl3, EtOAc, n-BuOH, H2O) from the stem bark of Ventilago leiocarpa Benth. The results showed that each fraction displayed both antiinflammatory and hepatoprotective activities, The H2O fraction (50, 100 mg/kg) was even more effective than indomethacin (10 mg/kg) in reducing carrageenin-induced oedema, and also had the greatest protection against CCl4-induced liver injury, It significantly lowered the acute increase in sGOT and sGPT levels caused by CCl4. Histopathological changes such as necrosis, fatty change, ballooning degeneration and inflammatory infiltration of lymphocytes and Kupffer cells around the central veins were also concurrently improved by the treatment with each fraction (50 mg/kg) or the H2O fraction (100 mg/kg).
引用
收藏
页码:11 / 15
页数:5
相关论文
共 11 条
[1]   DIVERSE EFFECTS OF SKF 525-A AND ANTIOXIDANTS ON CARBON TETRACHLORIDE-INDUCED CHANGES IN LIVER MICROSOMAL P-450 CONTENT AND ETHYLMORPHINE METABOLISM [J].
CASTRO, JA ;
SASAME, HA ;
SUSSMAN, H ;
GILLETTE, JR .
LIFE SCIENCES PART 1 PHYSIOLOGY AND PHARMACOLOGY AND PART 2 BIOCHEMISTRY GENERAL AND MOLECULAR BIOLOGY, 1968, 7 (3P1) :129-&
[2]   THE PHARMACOLOGICAL AND PATHOLOGICAL-STUDIES ON SEVERAL HEPATIC PROTECTIVE CRUDE DRUGS FROM TAIWAN .1. [J].
CHIU, HF ;
LIN, CC ;
YANG, CC ;
YANG, F .
AMERICAN JOURNAL OF CHINESE MEDICINE, 1988, 16 (3-4) :127-137
[3]   THE PHARMACOLOGICAL AND PATHOLOGICAL-STUDIES ON SEVERAL HEPATIC PROTECTIVE CRUDE DRUGS FROM TAIWAN(II) [J].
CHIU, HF ;
LIN, CC ;
YANG, CC ;
YANG, F .
AMERICAN JOURNAL OF CHINESE MEDICINE, 1989, 17 (1-2) :17-23
[4]  
KAN WS, 1975, PHARM BOTANY, P374
[5]   PHARMACOLOGICAL STUDIES ON THE CRUDE DRUG HWANG-JIN-GUEY FROM TAIWAN .1. [J].
LIN, CC ;
LIN, JM ;
CHANG, CH ;
HATTORI, M ;
NAMBA, T .
PHYTOTHERAPY RESEARCH, 1994, 8 (04) :193-200
[6]  
LITCHFIELD JT, 1949, J PHARMACOL EXP THER, V96, P99
[7]   A NEW APPROACH TO PRACTICAL ACUTE TOXICITY TESTING [J].
LORKE, D .
ARCHIVES OF TOXICOLOGY, 1983, 54 (04) :275-287
[8]  
RECKNAGE RO, 1967, PHARMACOL REV, V19, P145
[9]   A COLORIMETRIC METHOD FOR THE DETERMINATION OF SERUM GLUTAMIC OXALACETIC AND GLUTAMIC PYRUVIC TRANSAMINASES [J].
REITMAN, S ;
FRANKEL, S .
AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 1957, 28 (01) :56-63
[10]   ALTERATIONS IN MICROSOMAL ELECTRON TRANSPORT OXIDATIVE N-DEMETHYLATION AND AZO-DYE CLEAVAGE IN CARBON TETRACHLORIDE AND DIMETHYLNITROSAMINE-INDUCED LIVER INJURY [J].
SMUCKLER, EA ;
ARRHENIUS, E ;
HULTIN, T .
BIOCHEMICAL JOURNAL, 1967, 103 (01) :55-+