MOLECULAR-CLONING OF AN ORPHAN TRANSPORTER - A NEW MEMBER OF THE NEUROTRANSMITTER TRANSPORTER FAMILY

被引：34
|
作者：
SMITH, KE
FRIED, SG
DURKIN, MM
GUSTAFSON, EL
BORDEN, LA
BRANCHEK, TA
WEINSHANK, RL
机构：
[1] Synaptic Pharmaceutical Corporation, Paramus, NJ 07652
来源：
FEBS LETTERS | 1995年 / 357卷 / 01期
关键词：
TRANSPORTER; MESSENGER-RNA LOCALIZATION; MOLECULAR CLONING; ASTROCYTE; BRAIN (RAT);
D O I：
10.1016/0014-5793(94)01328-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A complementary DNA clone predicted to encode a novel transporter was isolated from rat brain and the localization of its mRNA was examined, The cDNA, designated rB21a, predicts a protein with 12 putative transmembrane domains that exhibits significant sequence homology with neurotransmitter transporters, Expression studies have not yet identified the endogenous substrate for this transporter, but the presence of rB21a mRNA within the leptomeninges of the brain suggests the transporter may regulate CSF levels of its substrate, The cloning of rB21a provides the means to determine its physiological functions and the potential to design novel, transporter-based therapeutic agents for neurological and psychiatric disorders.
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页码：86 / 92
页数：7
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