EFFECT OF CALCIUM - MODIFYING AGENTS ON THE GROWTH OF HUMAN GASTRIC-CARCINOMA CELLS-INVITRO

被引：0
作者：
PIONTEK, M
HENGELS, KJ
机构：
来源：
ANTICANCER RESEARCH | 1992年 / 12卷 / 05期
关键词：
AGS CELLS; GROWTH INHIBITION; CALCIUM; EDTA; W7; VERAPAMIL;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The antiproliferative effects of various calcium-modifying agents were investigated in human AGS gastric carcinoma cells in culture. Variation of the extracellular calcium concentration, achieved by addition of calcium to the growth medium or binding of calcium to the calcium-chelating agent EDTA, appeared to have little influence on growth of the tumor cells. In contrast, the calcium antagonist verapamil, the calcium ionophore A 23.187 and the calmodulin antagonist W 7, agents supposed to interfere with the regulation of the intracellular calcium concentration, all exerted marked growth inhibiting effects. Our results provide evidence for an important role of intracellular calcium-dependent mechanisms in growth regulation of the human gastric adenocarcinoma cell line AGS.
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页码：1559 / 1564
页数：6
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