NUCLEOTIDE-SEQUENCE OF THE SHV-5 BETA-LACTAMASE GENE OF A KLEBSIELLA-PNEUMONIAE PLASMID

被引：53

作者：

BILLOTKLEIN, D ^{[1
]}

GUTMANN, L ^{[1
]}

COLLATZ, E ^{[1
]}

机构：

[1] UNIV PARIS 06, MICROBIOL MED LAB, 15 RUE ECOLE MED, F-75270 PARIS 06, FRANCE

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 12期

关键词：

D O I：

10.1128/AAC.34.12.2439

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The nucleotide sequence of the SHV-5 β-lactamase gene, subcloned from a plasmid of Klebsiella pneumoniae, was determined. The amino acid changes thought to be responsible for the extended substrate profile of SHV-5 are Gly → Ser234 and Glu → Lys235. SHV-5 is identical to SHV-4, except for Leu → Arg201, which accounts for the difference in apparent pI of the two enzymes.

引用

页码：2439 / 2441

页数：3

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