THE GENE ENCODING THE MOK-2 ZINC-FINGER PROTEIN - CHARACTERIZATION OF ITS PROMOTER AND NEGATIVE REGULATION BY MOUSE ALU TYPE-2 REPETITIVE ELEMENTS

被引：19

作者：

ARRANZ, V ^{[1
]}

KRESS, M ^{[1
]}

ERNOULTLANGE, M ^{[1
]}

机构：

[1] LAB ONCOL MOLEC, F-94801 VILLEJUIF, FRANCE

来源：

GENE | 1994年 / 149卷 / 02期

关键词：

TISSUE-SPECIFIC GENE; DNA-BINDING PROTEIN; RNA-BINDING PROTEIN; TRANSCRIPTION; CAT REPORTER GENE; B2; SEQUENCES;

D O I：

10.1016/0378-1119(94)90164-3

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mouse gene MOK-2 encodes a protein with seven highly similar zinc fingers. The MOK-2 transcripts are preferentially detected in transformed cell lines, brain and testis tissues. The characterized 5'-flanking sequence differs from those of tissue-specific genes previously described. DNA sequence analysis shows that the promoter region lacks TATA and CCAAT boxes. Two short interspersed mouse genomic repeats (B2 sequences) found in this region exert a negative cis-acting effect on MOK-2 promoter activity.

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页码：293 / 298

页数：6

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