MAMMALIAN SMALL MOLECULE METHYLTRANSFERASES - THEIR STRUCTURAL AND FUNCTIONAL FEATURES

被引:44
作者
FUJIOKA, M
机构
来源
INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1992年 / 24卷 / 12期
关键词
D O I
10.1016/0020-711X(92)90287-B
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Structural and functional features of mammalian S-adenosyl-methionine-dependent small molecule methyltransferases are reviewed. The methyltransferases have similar protomer molecular weights in the range of 25,000-35,000. Two common sequence motifs are found in all enzymes of known sequence. When the kinetic mechanisms may be different, the methyltransferases in the free form bind S-adenosylmethionine. Most, if not all, of mammalian small molecule methyltransferases appear to have vicinal thiols in a catalytically important area of the enzyme.
引用
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页码:1917 / 1924
页数:8
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