MAMMALIAN SMALL MOLECULE METHYLTRANSFERASES - THEIR STRUCTURAL AND FUNCTIONAL FEATURES

被引：44
作者：
FUJIOKA, M
机构：
来源：
INTERNATIONAL JOURNAL OF BIOCHEMISTRY | 1992年 / 24卷 / 12期
关键词：
D O I：
10.1016/0020-711X(92)90287-B
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Structural and functional features of mammalian S-adenosyl-methionine-dependent small molecule methyltransferases are reviewed. The methyltransferases have similar protomer molecular weights in the range of 25,000-35,000. Two common sequence motifs are found in all enzymes of known sequence. When the kinetic mechanisms may be different, the methyltransferases in the free form bind S-adenosylmethionine. Most, if not all, of mammalian small molecule methyltransferases appear to have vicinal thiols in a catalytically important area of the enzyme.
引用
收藏
页码：1917 / 1924
页数：8
相关论文
共 63 条
[1]   SUBSTRATE-SPECIFICITY OF NICOTINAMIDE METHYLTRANSFERASE ISOLATED FROM PORCINE LIVER [J].
ALSTON, TA ;
ABELES, RH .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1988, 260 (02) :601-608
[2]   COMPLETE NUCLEOTIDE AND DEDUCED AMINO-ACID-SEQUENCE OF BOVINE PHENYLETHANOLAMINE N-METHYLTRANSFERASE - PARTIAL AMINO-ACID HOMOLOGY WITH RAT TYROSINE-HYDROXYLASE [J].
BAETGE, EE ;
SUH, YH ;
JOH, TH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1986, 83 (15) :5454-5458
[3]   HUMAN CATECHOL-O-METHYLTRANSFERASE - CLONING AND EXPRESSION OF THE MEMBRANE-ASSOCIATED FORM [J].
BERTOCCI, B ;
MIGGIANO, V ;
DAPRADA, M ;
DEMBIC, Z ;
LAHM, HW ;
MALHERBE, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (04) :1416-1420
[4]   CATECHOL-O-METHYLTRANSFERASE FROM HUMAN PLACENTA - PURIFICATION AND SOME PROPERTIES [J].
BHAIRD, NNA ;
TIPTON, KF .
BIOCHEMICAL SOCIETY TRANSACTIONS, 1991, 19 (01) :S20-S20
[5]   THE ENZYMIC N-METHYLATION OF GLYCINE [J].
BLUMENSTEIN, J ;
WILLIAMS, GR .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1960, 3 (03) :259-263
[6]   CATECHOL O-METHYLTRANSFERASE .1. KINETICS OF TROPOLONE INHIBITION [J].
BORCHARDT, RT .
JOURNAL OF MEDICINAL CHEMISTRY, 1973, 16 (04) :377-382
[7]   PURIFICATION AND CHARACTERIZATION OF RAT-HEART AND BRAIN CATECHOL METHYLTRANSFERASE [J].
BORCHARDT, RT ;
CHENG, CF .
BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 522 (01) :49-62
[8]  
CANTONI GL, 1951, J BIOL CHEM, V189, P745
[9]  
CANTONI GL, 1954, J BIOL CHEM, V209, P647
[10]   MEASUREMENT OF A FOLATE BINDING-PROTEIN FROM RAT-LIVER CYTOSOL BY RADIOIMMUNOASSAY [J].
COOK, RJ ;
WAGNER, C .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1981, 208 (02) :358-364
1234567