LACK OF JC VIRAL GENOMIC SEQUENCES IN MULTIPLE-SCLEROSIS BRAIN-TISSUE BY POLYMERASE CHAIN-REACTION

被引：33
|
作者：
BUCKLE, GJ
GODEC, MS
RUBI, JU
TORNATORE, C
MAJOR, EO
GIBBS, CJ
GAJDUSEK, DC
ASHER, DM
机构：
[1] NINCDS,MOLEC VIROL & GENET SECT,VIRAL & MOLEC PATHOGENESIS LAB,BETHESDA,MD 20892
[2] NINCDS,LCNSS,ROOM 5B21,BLDG 36,BETHESDA,MD 20892
来源：
ANNALS OF NEUROLOGY | 1992年 / 32卷 / 06期
关键词：
D O I：
10.1002/ana.410320622
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
With DNA extracted from brain specimens from 19 multiple sclerosis, 5 progressive multifocal leukoencephalopathy, 1 Alzheimer's disease, and 8 nonneurological control subjects, polymerase chain reaction was performed using nested sets of primer pairs amplifying segments of the large T and VPI antigen-encoding sequences of JC virus. Both sequences were detected in each of the 5 brain specimens of progressive multifocal leukoencephalopathy but in none of the 19 multiple sclerosis, 1 Alzheimer's disease, or the 8 control brain specimens.
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页码：829 / 831
页数：3
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