LACK OF JC VIRAL GENOMIC SEQUENCES IN MULTIPLE-SCLEROSIS BRAIN-TISSUE BY POLYMERASE CHAIN-REACTION

被引：33

作者：

BUCKLE, GJ

GODEC, MS

RUBI, JU

TORNATORE, C

MAJOR, EO

GIBBS, CJ

GAJDUSEK, DC

ASHER, DM

机构：

[1] NINCDS,MOLEC VIROL & GENET SECT,VIRAL & MOLEC PATHOGENESIS LAB,BETHESDA,MD 20892

[2] NINCDS,LCNSS,ROOM 5B21,BLDG 36,BETHESDA,MD 20892

来源：

ANNALS OF NEUROLOGY | 1992年 / 32卷 / 06期

关键词：

D O I：

10.1002/ana.410320622

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

With DNA extracted from brain specimens from 19 multiple sclerosis, 5 progressive multifocal leukoencephalopathy, 1 Alzheimer's disease, and 8 nonneurological control subjects, polymerase chain reaction was performed using nested sets of primer pairs amplifying segments of the large T and VPI antigen-encoding sequences of JC virus. Both sequences were detected in each of the 5 brain specimens of progressive multifocal leukoencephalopathy but in none of the 19 multiple sclerosis, 1 Alzheimer's disease, or the 8 control brain specimens.

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页码：829 / 831

页数：3

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