LACK OF JC VIRAL GENOMIC SEQUENCES IN MULTIPLE-SCLEROSIS BRAIN-TISSUE BY POLYMERASE CHAIN-REACTION

被引：33
作者：
BUCKLE, GJ
GODEC, MS
RUBI, JU
TORNATORE, C
MAJOR, EO
GIBBS, CJ
GAJDUSEK, DC
ASHER, DM
机构：
[1] NINCDS,MOLEC VIROL & GENET SECT,VIRAL & MOLEC PATHOGENESIS LAB,BETHESDA,MD 20892
[2] NINCDS,LCNSS,ROOM 5B21,BLDG 36,BETHESDA,MD 20892
来源：
ANNALS OF NEUROLOGY | 1992年 / 32卷 / 06期
关键词：
D O I：
10.1002/ana.410320622
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
With DNA extracted from brain specimens from 19 multiple sclerosis, 5 progressive multifocal leukoencephalopathy, 1 Alzheimer's disease, and 8 nonneurological control subjects, polymerase chain reaction was performed using nested sets of primer pairs amplifying segments of the large T and VPI antigen-encoding sequences of JC virus. Both sequences were detected in each of the 5 brain specimens of progressive multifocal leukoencephalopathy but in none of the 19 multiple sclerosis, 1 Alzheimer's disease, or the 8 control brain specimens.
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页码：829 / 831
页数：3
相关论文
共 14 条
  • [1] PERSISTENCE OF DNA-SEQUENCES OF BK VIRUS AND JC VIRUS IN NORMAL HUMAN-TISSUES AND IN DISEASED TISSUES
    CHESTERS, PM
    HERITAGE, J
    MCCANCE, DJ
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1983, 147 (04) : 676 - 684
  • [2] DETECTION OF MEASLES-VIRUS GENOMIC SEQUENCES IN SSPE BRAIN-TISSUE BY THE POLYMERASE CHAIN-REACTION
    GODEC, MS
    ASHER, DM
    SWOVELAND, PT
    ELDADAH, ZA
    FEINSTONE, SM
    GOLDFARB, LG
    GIBBS, CJ
    GAJDUSEK, DC
    [J]. JOURNAL OF MEDICAL VIROLOGY, 1990, 30 (04) : 237 - 244
  • [3] ABSENCE OF MEASLES, MUMPS, AND RUBELLA VIRAL GENOMIC SEQUENCES FROM MULTIPLE-SCLEROSIS BRAIN-TISSUE BY POLYMERASE CHAIN-REACTION
    GODEC, MS
    ASHER, DM
    MURRAY, RS
    SHIN, ML
    GREENHAM, LW
    GIBBS, CJ
    GAJDUSEK, DC
    [J]. ANNALS OF NEUROLOGY, 1992, 32 (03) : 401 - 404
  • [4] GODEC MS, 1992, IN PRESS DIAGNOSIS H
  • [5] AMPLIFICATION OF JC VIRUS-DNA FROM BRAIN AND CEREBROSPINAL-FLUID OF PATIENTS WITH PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY
    HENSON, J
    ROSENBLUM, M
    ARMSTRONG, D
    FURNEAUX, H
    [J]. NEUROLOGY, 1991, 41 (12) : 1967 - 1971
  • [6] EPIDEMIOLOGIC CONTRIBUTIONS TO MULTIPLE-SCLEROSIS - AN OVERVIEW
    KURTZKE, JF
    [J]. NEUROLOGY, 1980, 30 (07) : 61 - 79
  • [7] PATHOGENESIS AND MOLECULAR-BIOLOGY OF PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY, THE JC VIRUS-INDUCED DEMYELINATING DISEASE OF THE HUMAN BRAIN
    MAJOR, EO
    AMEMIYA, K
    TORNATORE, CS
    HOUFF, SA
    BERGER, JR
    [J]. CLINICAL MICROBIOLOGY REVIEWS, 1992, 5 (01) : 49 - 73
  • [8] INVITRO-LABELED DNA FOR DETECTING VIRAL GENOMES IN MULTIPLE-SCLEROSIS .1. PAPOVAVIRUSES
    MEINKE, W
    SMITH, RA
    LANCASTER, WD
    GOLDSTEIN, DA
    TOURTELLOTTE, WW
    SPIZIZEN, J
    [J]. NEUROLOGY, 1977, 27 (08) : 736 - 740
  • [9] MILLER NR, 1983, POLYOMAVIRUSES HUMAN, P29
  • [10] MULLIS KB, 1987, METHOD ENZYMOL, V155, P335
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