ALPHA-FETOPROTEIN PRODUCTION BY HEPATOCELLULAR-CARCINOMA IS PROGNOSTIC OF POOR PATIENT SURVIVAL

被引：40

作者：

IZUMI, R ^{[1
]}

SHIMIZU, K ^{[1
]}

KIRIYAMA, M ^{[1
]}

HASHIMOTO, T ^{[1
]}

URADE, M ^{[1
]}

YAGI, M ^{[1
]}

MIZUKAMI, Y ^{[1
]}

NONOMURA, A ^{[1
]}

MIYAZAKI, I ^{[1
]}

机构：

[1] KANAZAWA UNIV HOSP,PATHOL SECT,KANAZAWA,JAPAN

来源：

JOURNAL OF SURGICAL ONCOLOGY | 1992年 / 49卷 / 03期

关键词：

HEPATIC RESECTION; IMMUNOHISTOCHEMISTRY; SERUM ALPHA-FETOPROTEIN LEVEL;

D O I：

10.1002/jso.2930490305

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immunohistochemistry using the avidin-biotin-peroxidase complex method was performed to study the production of alpha-fetoprotein (AFP) in hepatocellular carcinoma (HCC) tissue specimens which were obtained surgically. The relationship between staining for AFP and serum AFP levels or pathological findings was examined. The prognosis of the patients with HCC who underwent curative hepatic resections was studied with respect to the staining for AFP in their tumors. The mean serum AFP level in patients with positive AFP staining was significantly higher than in those with negative AFP staining. No significant relationship was found between AFP positivity and tumor size, tumor encapsulation, degree of vascular invasion, or the histological differentiation grade of the tumor. The patients with AFP-positive carcinomas had a poorer prognosis than did those with AFP-negative carcinomas (5-year survival rate of AFP-positive and negative groups were 26.7% and 56.5%, respectively).

引用

页码：151 / 155

页数：5

共 23 条

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