INVOLVEMENT OF HISTAMINERGIC NEURONS IN AROUSAL MECHANISMS DEMONSTRATED WITH H-3 RECEPTOR LIGANDS IN THE CAT

被引：175

作者：

LIN, JS ^{[1
]}

SAKAI, K ^{[1
]}

VANNIMERCIER, G ^{[1
]}

ARRANG, JM ^{[1
]}

GARBARG, M ^{[1
]}

SCHWARTZ, JC ^{[1
]}

JOUVET, M ^{[1
]}

机构：

[1] INSERM, CTR PAUL BROCA, UNITE NEUROBIOL 109, F-75005 PARIS, FRANCE

来源：

BRAIN RESEARCH | 1990年 / 523卷 / 02期

关键词：

Cat; H[!sub]3[!/sub]-receptor; Histaminergic neuron; Sleep-wakefulness; Thioperamide; α-Methylhistamine;

D O I：

10.1016/0006-8993(90)91508-E

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of histamine H3-receptor ligands on sleep-waking parameters were studied in freely moving cats. Oral administration of (R)α-methylhistamine (αMHA), a H3-agonist, caused a significant increase in deep slow wave sleep while that of thioperamide, a H3-antagonist, enhanced wakefulness in a marked and dose-dependent manner. The arousal effects of thioperamide were prevented by pretreatment with αMHA or mepyramine, a H1-receptor antagonist. The findings support the hypothesis that the histaminergic neurons are critically involved in arousal mechanisms and suggest that H3-receptors play an active part in these mechanisms by regulating histamine transmission. © 1990.

引用

页码：325 / 330

页数：6

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