ROLE OF THE EXCITOTOXIC MECHANISM IN THE DEVELOPMENT OF NEURONAL DAMAGE FOLLOWING REPEATED BRIEF CEREBRAL-ISCHEMIA IN THE GERBIL - PROTECTIVE EFFECTS OF MK-801 AND PENTOBARBITAL

被引：56

作者：

KATO, H

ARAKI, T

KOGURE, K

机构：

[1] Department of Neurology, Institute of Brain Diseases, Tohoku University School of Medicine, Sendai

来源：

BRAIN RESEARCH | 1990年 / 516卷 / 01期

关键词：

Cerebral ischemia; Flunarizine; Gerbil; MK-801; Pentobarbital; Repeated ischemia; Selective vulnerability;

D O I：

10.1016/0006-8993(90)90916-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Pretreatment with MK-801 (an NMDA antagonist) or pentobarbital (a GABAA receptor-effector) ameliorated histopathological neuronal damage to the hippocampal CA1 subfield and to the thalamus following three 2-min forebrain ischemia at 1-h intervals in the gerbil. Flunarizine, a calcium antagonist, failed to prevent the neuronal damage. The results suggest that the excitotoxic mechanism plays a role in the neuronal damage following repeated ischemia. © 1990.

引用

页码：175 / 179

页数：5

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AAKI T, IN PRESS RES EXP MED

[2] COMPARATIVE PROTECTIVE EFFECTS OF NICARDIPINE, FLUNARIZINE, LIDOFLAZINE AND NIMODIPINE AGAINST ISCHEMIC-INJURY IN THE HIPPOCAMPUS OF THE MONGOLIAN GERBIL [J].