ROLE OF THE EXCITOTOXIC MECHANISM IN THE DEVELOPMENT OF NEURONAL DAMAGE FOLLOWING REPEATED BRIEF CEREBRAL-ISCHEMIA IN THE GERBIL - PROTECTIVE EFFECTS OF MK-801 AND PENTOBARBITAL

被引：56
|
作者：
KATO, H
ARAKI, T
KOGURE, K
机构：
[1] Department of Neurology, Institute of Brain Diseases, Tohoku University School of Medicine, Sendai
来源：
BRAIN RESEARCH | 1990年 / 516卷 / 01期
关键词：
Cerebral ischemia; Flunarizine; Gerbil; MK-801; Pentobarbital; Repeated ischemia; Selective vulnerability;
D O I：
10.1016/0006-8993(90)90916-Y
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Pretreatment with MK-801 (an NMDA antagonist) or pentobarbital (a GABAA receptor-effector) ameliorated histopathological neuronal damage to the hippocampal CA1 subfield and to the thalamus following three 2-min forebrain ischemia at 1-h intervals in the gerbil. Flunarizine, a calcium antagonist, failed to prevent the neuronal damage. The results suggest that the excitotoxic mechanism plays a role in the neuronal damage following repeated ischemia. © 1990.
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页码：175 / 179
页数：5
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