ANABOLIC EFFECTS IN MAN OF PAPAIN DIGESTS OF BOVINE GROWTH HORMONE

被引：12
作者：
SONENBERG, M
DELLACHA, JM
机构：
来源：
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 1967年 / 27卷 / 07期
关键词：
D O I：
10.1210/jcem-27-7-1035
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Bovine growth hormone has been digested with papain. Proteolysis of the protein for 2 hr. resulted in no loss of growth promoting activity in the hypophysectomized rat. After 3 hr. of papain digestion of bovine growth hormone, only one new major electrophoretic component appeared. Exposure to papain for 6 hr. produced no appreciable loss of growth promoting activity. When the papain digested growth hormone was administered to 2 hypopituitary patients, one diabetic and one nondiabetic, there was an anabolic effect in both without evidence of diabetogenicity in either.
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页码：1035 / +
页数：1
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