SYNTHESIS OF STEREOSPECIFICALLY LABELED D-PROP-2-YNYLGLYCINE AND INVESTIGATION OF THE ACTION OF D-AMINO-ACID OXIDASE

被引：15

作者：

CHURCH, NJ ^{[1
]}

YOUNG, DW ^{[1
]}

机构：

[1] UNIV SUSSEX,SCH CHEM & MOLEC SCI,BRIGHTON BN1 9QJ,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 08期

关键词：

D O I：

10.1039/c39940000943

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Stereospecifically deuteriated samples of D-prop-2-ynylglycine 1 are synthesised by reaction of the labelled aziridines 13 with a carbon nucleophile followed by deprotection; incubation of these samples with D-amino acid oxidase indicates that, in formation of the lactone 5, deprotonation at C-3 is non-stereospecific, strongly supporting non-enzymatic deprotonation as a key step in the formation of this compound.

引用

页码：943 / 944

页数：2

共 8 条

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