VCAM-1 IS A RECEPTOR FOR ENCEPHALOMYOCARDITIS VIRUS ON MURINE VASCULAR ENDOTHELIAL-CELLS

被引：73

作者：

HUBER, SA

机构：

来源：

JOURNAL OF VIROLOGY | 1994年 / 68卷 / 06期

关键词：

D O I：

10.1128/JVI.68.6.3453-3458.1994

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Murine VCAM-1 has been identified as a receptor for the D variant of encephalomyocarditis (EMC-D) virus on vascular endothelial cells from the heart. Monoclonal antibodies to VCAM-1 inhibited infection and lysis of endothelial cells with EMC-D virus. CHO cells transfected with the VCAM-1 gene were susceptible to ER IC-D virus lysis, while control CHO cells transfected with the ELAM-1 gene were resistant. Similarly, S-35-labeled EMC-D virus bound to CHO-VCAM cells, and binding was inhibited with anti-VCAM-1 antibodies. Little or no radiolabeled virus bound to CHO-ELAM-1 cells.

引用

页码：3453 / 3458

页数：6

共 32 条

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