SUCCESSFUL TREATMENT OF T-GAMMA-LYMPHOPROLIFERATIVE DISEASE WITH HUMAN-RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR

A trial of recombinant human granulocyte colony-stimulating factor (rhG-CSF) was attempted in a male with agranulocytosis, infection, and T-gamma lymphoproliferative disease (T-gamma-LPD). During five days of rhG-CSF (960-mu-g/day), the absolute neutrophil count (ANC) increased from 0.0 to 4.5 K/mu-l. There were no changes in eosinophil or lymphocyte counts. In addition, there was no toxicity. Bone marrow cytotoxic/suppressor cells (CD57+/CD8+) were elevated (21.9%) before and decreased to 10.6% (normal < 12%) following rhG-CSF. By contrast, there was no change in activated T cells (CD3+DR+) or T cell gene rearrangements. These findings suggest rhG-CSF can improve granulopoiesis in T-gamma-LPD, possibly by altering T-cell mediated marrow suppression.