THE PHYLOGENY OF ENKEPHALINS - SPECULATIONS ON THE ORIGINS OF OPIOID PRECURSORS

被引：27

作者：

DORES, RM ^{[1
]}

MCDONALD, LK ^{[1
]}

GOLDSMITH, A ^{[1
]}

DEVICHE, P ^{[1
]}

RUBIN, DA ^{[1
]}

机构：

[1] UNIV ALASKA,INST ARCTIC BIOL,FAIRBANKS,AK 99701

来源：

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 1993年 / 3卷 / 3-4期

关键词：

ENKEPHALINS; PRODYNORPHIN; PROENKEPHALIN; PROOPIOMELANOCORTIN;

D O I：

10.1159/000154686

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Enkephalins, dynorphins and beta-endorphin are endogenous opiate-like substances that are differentially distributed among vertebrate taxa. Enkephalins have the widest distribution, and the proenkephalin gene would appear to represent the ancestral opioid gene. This review will consider the following hypothesis: the evolution of the opioids occurred as a result of two duplications of the proenkephalin gene. In this hypothesis, the first duplication event would have given rise to the proopiomelanocortin gene, the precursor for beta-endorphin, and the second duplication event would have given rise to the prodynorphin gene.

引用

页码：231 / 244

页数：14

共 50 条

[1]

Baker B, 1979, HORMONE EVOLUTION, P643

[2] THE MOLECULAR EVOLUTION OF NEUROPEPTIDES - PROSPECTS FOR THE 90S [J].