INTERFERON TRANSIENTLY MODULATES INTRANUCLEAR SIGNALING SYSTEM IN ERYTHROLEUKEMIA FRIEND-CELLS

被引：26
作者：
MISCIA, S
CATALDI, A
LISIO, R
TULIPANO, G
RIZZOLI, R
RANA, R
COCCO, L
机构：
[1] CNR, IST CITOMORFOL NORMALE & PATOL, CHIETI, ITALY
[2] UNIV BOLOGNA, IST ANAT UMANA NORMALE, I-40126 BOLOGNA, ITALY
来源：
CELL BIOLOGY INTERNATIONAL REPORTS | 1991年 / 15卷 / 05期
关键词：
D O I：
10.1016/0309-1651(91)90130-B
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The effect of human recombinant DNA interferon alpha type A on nuclear inositol lipids, diacylglycerol (DAG) and DNA metabolism has been investigated in Friend erythroleukemia cells. A transient enhancement of phosphatidylinositol (4,5) - bisphosphate (PIP2) phosphorylation together with an increase of diacylglycerol mass were observed in nuclei isolated from cells treated with interferon alpha for 90 min. At the same time, a marked reduction of DNA polymerase alpha activity was observed, suggesting a possible involvement of nuclear inositol fraction in the response of the cell nucleus to interferon treatment. © 1991.
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页码：427 / 435
页数：9
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