EXPERIMENTAL INDUCED PANCREATIC-CARCINOMA AFTER CHOLEDOCHOJEJUNOSTOMY

被引：4
作者：
RUCKERT, K [1 ]
KLINK, E [1 ]
KLOPPEL, G [1 ]
机构：
[1] UNIV HAMBURG,INST PATHOL,D-2000 HAMBURG 20,FED REP GER
来源：
LANGENBECKS ARCHIV FUR CHIRURGIE | 1979年 / 348卷 / 04期
关键词：
Bile reflux; Nitrosamine; Pancreatic carcinoma;
D O I：
10.1007/BF01317612
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
The pancreatic carcinogen DHPN (dihydroxypropylnitrosamin) was administered to Syrian golden hamsters. By intragastric administration more pancreatic carcinomas in the head of the gland were induced than by subcutaneous injections. After choledochojejunostomy the incidence of carcinomas was only 5 - 7% and the lesions were similar in multiplicity and distribution without relationship to the way of administration. The importance of biliary reflux in pancreatic tumor induction is discussed and the role of bile concerning the preferred localisation of the tumors in the head of the pancreas. © 1979 Springer-Verlag.
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页码：261 / 268
页数：8
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