THYMUS DERIVED INHIBITOR OF LYMPHOCYTE-PROLIFERATION .1. ISOLATION AND ASSESSMENT OF TISSUE-SPECIFICITY

被引：4
作者：
RIJKE, EO
BALLIEUX, RE
机构：
[1] Department of Clinical Immunology, University Hospital, Utrecht
来源：
CELL AND TISSUE KINETICS | 1979年 / 12卷 / 04期
关键词：
D O I：
10.1111/j.1365-2184.1979.tb00166.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Preparations from bovine thymus tissue were analyzed for their inhibitory effects during in vitro lymphocyte proliferation. The results indicate that these preparations strongly inhibit DNA synthesis in stimulated human peripheral lymphocytes, bone marrow cells, thymocytes and lymphoblastoid cells. This inhibition was dose‐dependent and not due to cytotoxicity of the preparations. No inhibition was found of the spontaneous proliferation of HeLa cells and human fibroblasts indicating that the inhibitory effect was specific for proliferating lymphocytes. Control preparations from bovine liver or kidney did not show any suppression in the test systems used. Copyright © 1979, Wiley Blackwell. All rights reserved
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页码：435 / 444
页数：10
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