EFFECT OF AMITRIPTYLINE ON PULMONARY VENTILATION AND MECHANICS OF BREATHING

被引：11

作者：

AVNI, J

BRUDERMA.I

机构：

[1] Department of Psychiatry and Cardiopulmonary Laboratory, Hadassah-Hebrew University Hospital, Jerusalem

来源：

PSYCHOPHARMACOLOGIA | 1969年 / 14卷 / 03期

关键词：

Amitriptyline; Asthma; Breathing; Lungs; Respiration;

D O I：

10.1007/BF00404216

中图分类号：

B849 [应用心理学];

学科分类号：

040203 ;

摘要：

The effect of amitriptyline on pulmonary ventilation and mechanics in both intact and vagotomized dogs was investigated. Injection of amitriptyline, 2.5 mg/kg i.v., caused bronchodilation of short duration and marked inhibition of serotonin- or histamine-induced bronchoconstriction for a period up to two hours. This inhibitory effect persisted after vagotomy. Tachypnea followed each injection of amitriptyline and this was abolished by vagotomy. The mechanism of the different actions of the drug on the respiratory system is discussed. © 1969 Springer-Verlag.

引用

页码：184 / &

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