SYNTHESIS OF TAXOL FROM BACCATIN-3 VIA AN OXAZOLINE INTERMEDIATE

被引：67
作者：
KINGSTON, DGI
CHAUDHARY, AG
GUNATILAKA, AAL
MIDDLETON, ML
机构：
[1] Department of Chemistry, Virginia Polytechnic Institute, State University Blacksburg
来源：
TETRAHEDRON LETTERS | 1994年 / 35卷 / 26期
关键词：
D O I：
10.1016/S0040-4039(00)60706-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Taxol (1) can be prepared in good yield by coupling the oxazoline carboxylic acid 5 with 7-(triethylsilyl)baccatin III, followed by hydrolysis. The oxazolines 7 and 8 can also be prepared directly from taxol.
引用
收藏
页码：4483 / 4484
页数：2
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