THE N-TERMINUS OF AMINE OXIDASE OF HANSENULA-POLYMORPHA CONTAINS A PEROXISOMAL TARGETING SIGNAL

被引：49
作者：
FABER, KN
KEIZERGUNNINK, I
PLUIM, D
HARDER, W
AB, G
VEENHUIS, M
机构：
[1] UNIV GRONINGEN,CTR BIOL,DEPT MICROBIOL,9751 NN HAREN,NETHERLANDS
[2] UNIV GRONINGEN,BIOCHEM LAB,9747 AG GRONINGEN,NETHERLANDS
来源：
FEBS LETTERS | 1995年 / 357卷 / 02期
关键词：
PEROXISOME; TOPOGENIC SIGNAL; AMINE OXIDASE; PTS2; BETA-LACTAMASE; WATERMELON MALATE DEHYDROGENASE;
D O I：
10.1016/0014-5793(94)01317-T
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Here we describe the identification of the targeting sequence of peroxisomal amine oxidase (AMO) of H. polymorpha. Deletion analysis revealed that essential targeting information is located within the extreme N-terminal 16 amino acids. Moreover, this sequence can direct a reporter protein to the peroxisomal matrix of H. polymorpha. The N-terminal 16 amino acids of AMO contain a sequence with strong homology to the conserved PTS2 sequence. Therefore, AMO is considered to be a PTS2 protein.
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页码：115 / 120
页数：6
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