EFFECT OF ALDOSE REDUCTASE INHIBITOR ON THE INHIBITION OF PLATELET-AGGREGATION INDUCED BY DIABETIC RAT PLASMA

被引：8
作者：
TAKIGUCHI, Y
WADA, K
NAKASHIMA, M
机构：
[1] Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 215卷 / 2-3期
关键词：
ALDOSE REDUCTASE INHIBITORS; PLATELET AGGREGATION; DIABETES; (RAT);
D O I：
10.1016/0014-2999(92)90041-2
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Plasma isolated from streptozotocin-induced diabetic rats inhibited platelet aggregation. Treatment of diabetic rats with an aldose reductase inhibitor, ONO-2235, which did not improve hyperglycemia, prevented the antiaggregating activity of plasma as did insulin treatment. Both treatments reduced the elevated sorbitol concentrations in erythrocytes. Although the factor(s) accounting for the antiaggregatory effect of diabetic plasma has not yet been characterized, it is possible that the accumulation of sorbitol in erythrocytes is related to the generation of the factor(s).
引用
收藏
页码：289 / 291
页数：3
相关论文
共 11 条
  • [1] BULT H, 1991, THROMB HAEMOSTASIS, V66, P343
  • [2] EFFECT OF STREPTOZOTOCIN DIABETES ON PLATELET-FUNCTION IN RATS
    ELDOR, A
    MERIN, S
    BARON, H
    [J]. THROMBOSIS RESEARCH, 1978, 13 (05) : 703 - 714
  • [3] HASHIMOTO H, 1990, J PHARMACOL EXP THER, V253, P552
  • [4] ROLE OF ALDOSE REDUCTASE IN THE DEVELOPMENT OF DIABETES-ASSOCIATED COMPLICATIONS
    KADOR, PF
    KINOSHITA, JH
    [J]. AMERICAN JOURNAL OF MEDICINE, 1985, 79 (5A) : 8 - 12
  • [5] PLATELET AGGREGABILITY DURING THE 1ST 2 YEARS OF TYPE-1 (INSULIN-DEPENDENT) DIABETES-MELLITUS IN CHILDREN
    KOBBAH, AM
    EWALD, U
    TUVEMO, T
    [J]. DIABETOLOGIA, 1989, 32 (10) : 729 - 735
  • [6] LIAO JC, 1988, CLIN CHEM, V34, P2327
  • [7] RED-BLOOD-CELL SORBITOL AS AN INDICATOR OF POLYOL PATHWAY ACTIVITY - INHIBITION BY SORBINIL IN INSULIN-DEPENDENT DIABETIC SUBJECTS
    MALONE, JI
    LEAVENGOOD, H
    PETERSON, MJ
    OBRIEN, MM
    PAGE, MG
    ALDINGER, CE
    [J]. DIABETES, 1984, 33 (01) : 45 - 49
  • [8] GLUCOSE INCREASES SPONTANEOUS PLATELET-AGGREGATION IN WHOLE-BLOOD
    MAY, J
    LOESCHE, W
    HEPTINSTALL, S
    [J]. THROMBOSIS RESEARCH, 1990, 59 (03) : 489 - 495
  • [9] REGULATION OF PLATELET-AGGREGATION AND ARACHIDONATE METABOLISM IN STREPTOZOTOCIN-DIABETIC RATS
    TAKAHASHI, R
    MORITA, I
    MUROTA, S
    ITO, H
    [J]. PROSTAGLANDINS LEUKOTRIENES AND MEDICINE, 1986, 25 (2-3): : 123 - 129
  • [10] EFFECT OF DIABETES ON PHOTOCHEMICALLY INDUCED THROMBOSIS IN FEMORAL-ARTERY AND PLATELET-AGGREGATION IN RATS
    TAKIGUCHI, Y
    WADA, K
    MATSUNO, H
    NAKASHIMA, M
    [J]. THROMBOSIS RESEARCH, 1991, 63 (04) : 445 - 456
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