DIMETHYL-SULFOXIDE AND HEMIN INDUCE FERROCHELATASE MESSENGER-RNA BY DIFFERENT MECHANISMS IN MURINE ERYTHROLEUKEMIA-CELLS

被引:16
作者
FUKUDA, Y
FUJITA, H
TAKETANI, S
SASSA, S
机构
[1] ROCKEFELLER UNIV,NEW YORK,NY 10021
[2] KANSAI MED UNIV,MORIGUCHI,OSAKA 570,JAPAN
关键词
D O I
10.1111/j.1365-2141.1993.tb04674.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The level of mRNA encoding ferrochelatase (FeC), the terminal enzyme of the haem biosynthetic pathway, was examined in murine erythroleukaemia (MEL) cells when they were induced to undergo erythroid cell differentiation by treatment with dimethyl sulphoxide (DMSO), or haemin. FeC mRNA increased within 12 h after DMSO or haemin treatment of MEL cells, and its level continued to increase for 48 h. Treatment of cells with succinylacetone (SA), a potent inhibitor of haem synthesis, suppressed a DMSO-mediated increase in FeC mRNA, and haemin treatment reversed a SA-mediated decrease in FeC mRNA. Nuclear runoff analyses showed that, while DMSO increased the rate of transcription of FeC mRNA, haemin did not. These results indicate that the induction of FeC mRNA by DMSO is largely transcriptional, while that by haemin is post-transcriptional.
引用
收藏
页码:480 / 484
页数:5
相关论文
共 40 条
  • [1] ECLECTIC MECHANISMS OF HEME REGULATION OF HEMATOPOIESIS
    ABRAHAM, NG
    LEVERE, RD
    LUTTON, JD
    [J]. INTERNATIONAL JOURNAL OF CELL CLONING, 1991, 9 (03): : 185 - 210
  • [2] MOLECULAR REGULATION - BIOLOGICAL ROLE OF HEME IN HEMATOPOIESIS
    ABRAHAM, NG
    [J]. BLOOD REVIEWS, 1991, 5 (01) : 19 - 28
  • [3] EXPRESSION OF HEME OXYGENASE GENE IN RAT AND HUMAN-LIVER
    ABRAHAM, NG
    LIN, JHC
    MITRIONE, SM
    SCHWARTZMAN, ML
    LEVERE, RD
    SHIBAHARA, S
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 150 (02) : 717 - 722
  • [4] ALAM J, 1989, J BIOL CHEM, V264, P6371
  • [5] ALTER BP, 1989, ADV EXP MED BIOL, V271, P95
  • [6] INTRACELLULAR HEME COORDINATELY MODULATES GLOBIN CHAIN SYNTHESIS, TRANSFERRIN RECEPTOR NUMBER, AND FERRITIN CONTENT IN DIFFERENTIATING FRIEND-ERYTHROLEUKEMIA CELLS
    BATTISTINI, A
    COCCIA, EM
    MARZIALI, G
    BULGARINI, D
    SCALZO, S
    FIORUCCI, G
    ROMEO, G
    AFFABRIS, E
    TESTA, U
    ROSSI, GB
    PESCHLE, C
    [J]. BLOOD, 1991, 78 (08) : 2098 - 2103
  • [7] A METHOD FOR ISOLATION OF INTACT, TRANSLATIONALLY ACTIVE RIBONUCLEIC-ACID
    CATHALA, G
    SAVOURET, JF
    MENDEZ, B
    WEST, BL
    KARIN, M
    MARTIAL, JA
    BAXTER, JD
    [J]. DNA-A JOURNAL OF MOLECULAR & CELLULAR BIOLOGY, 1983, 2 (04): : 329 - 335
  • [8] CHERTKOV JL, 1991, EXP HEMATOL, V19, P905
  • [9] MULTIPLE MECHANISMS FOR THE REGULATION OF HEME-SYNTHESIS DURING ERYTHROID CELL-DIFFERENTIATION - POSSIBLE ROLE FOR COPROPORPHYRINOGEN OXIDASE
    CONDER, LH
    WOODARD, SI
    DAILEY, HA
    [J]. BIOCHEMICAL JOURNAL, 1991, 275 : 321 - 326
  • [10] INCREASE IN GLOBIN CHAINS AND GLOBIN MESSENGER-RNA IN ERYTHROLEUKEMIA CELLS IN RESPONSE TO HEMIN
    DABNEY, BJ
    BEAUDET, AL
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1977, 179 (01) : 106 - 112