SKH-1 HAIRLESS MICE REPAIR UV-INDUCED PYRIMIDINE DIMERS IN EPIDERMAL DNA

被引：35
|
作者：
YAROSH, DB
YEE, V
机构：
[1] Applied Genitics Inc., Freeport, NY 11520
来源：
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY | 1990年 / 7卷 / 2-4期
关键词：
epidermis; Pyrimidine dimers; SKH-1 hairless mouse; T4 endonuclease V; UV light;
D O I：
10.1016/1011-1344(90)85154-O
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The SKH-1 hairless mouse strain has been used extensively as a model for human photocarcinogenesis, photoimmunology and photoaging, but little is known about DNA repair in living mouse skin. Mice were irradiated with UV-B light at doses which produce mild to severe sunburn, and the frequency of pyrimidine dimers in epidermal DNA was measured immediately and 6 h after irradiation using T4 endonuclease V treatment and alkaline agarose gel electrophoresis. The results demonstrate significant removal of pyrimidine dimers in mouse skin in vivo, with a dimer half-life of 7.4 h. These findings are similar to the repair of dimers in human skin in vivo. The SKH-1 hairless mouse is thus a useful model for pyrimidine dimer repair in human skin. © 1990.
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收藏
页码：173 / 179
页数：7
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