RENIN-ANGIOTENSIN SYSTEM INHIBITION IN CONSCIOUS SODIUM-DEPLETED DOGS - EFFECTS ON SYSTEMIC AND CORONARY HEMODYNAMICS

被引:97
作者
LIANG, CS
GAVRAS, H
HOOD, WB
机构
[1] BOSTON UNIV, SCH MED, DEPT PHARMACOL, BOSTON, MA 02118 USA
[2] BOSTON UNIV, SCH MED, INST CARDIOVASC, BOSTON, MA 02118 USA
[3] BOSTON CITY HOSP, DEPT CARDIOL, MED SERV, BOSTON, MA 02118 USA
[4] BOSTON CITY HOSP, DEPT HYPERTENS, MED SERV, BOSTON, MA 02118 USA
[5] BOSTON CITY HOSP, THORNDIKE MEM LABS, BOSTON, MA 02118 USA
[6] UNIV HOSP BOSTON, DEPT MED, BOSTON, MA 02118 USA
[7] UNIV HOSP BOSTON, DEPT CLIN RES, BOSTON, MA 02118 USA
关键词
D O I
10.1172/JCI109013
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
The role of the renin-angiotensin system in the regulation of the systemic and coronary circulations during sodium depletion was studied in conscious normotensive dogs by i.v. administration of teprotide (0.5 mg/kg), an angiotensin-converting enzyme inhibitor, and saralasin (0.05-5 μg/kg per min), an angiotensin-receptor antagonist. Sodium depletion was produced by administering a low sodium diet and furosemide for 5 days. Administration of both teprotide and saralasin lowered systemic arterial blood pressure and total peripheral vascular resistance. Simultaneously, cardiac output increased, but left ventricular end-diastolic pressure, dP/dt, and dP/dt/P did not change significantly. Furthermore, both agents reduced diastolic coronary vascular resistance and increased coronary blood flow, but did not affect myocardial oxygen consumption, left ventricular work, or myocardial efficiency. These systemic and coronary vasodilator effects of teprotide and saralasin, however, were not observed in normal dogs on a regular sodium diet; in this group, the only effect noted was a slight increase in arterial pressure during saralasin infusion. Arterial plasma concentration of norepinephrine did not differ between normal and sodium-depleted dogs, nor did it change significantly after teprotide administration. These results suggest that, during salt depletion, angiotensin II exerts an active vasoconstrictor action on the systemic and coronary vessels, but has no significant effects on myocardial contractility or energetics. It also appears likely that the increase in cardiac output observed in sodium-depleted dogs after angiotensin inhibition was caused, at least in part, by the decrease in systemic arterial pressure.
引用
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页码:874 / 883
页数:10
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