ANGIOTENSIN I-CONVERTING ENZYME-ACTIVITY IN RATS WITH CARBON TETRACHLORIDE-INDUCED ACUTE-RENAL-FAILURE

被引：8
作者：
PEDRAZACHAVERRI, J
CRUZ, C
HERNANDEZPANDO, R
SANTANA, T
AREVALO, AE
GONZALEZ, L
TAPIA, E
PENA, JC
PANDURO, A
机构：
[1] Department of Nephrology and Mineral Metabolism, Instituto Nacional de la Nutrición, Salvador, Zubirán
[2] Department of Pathology, Instituto Nacional de la Nutrición, Salvador, Zubirán
[3] Department of Gastroenterology, Instituto Nacional de la Nutrición, Salvador, Zubirán
[4] Department of Nephrology, Instituto Nacional de Cardiologia
来源：
RENAL FAILURE | 1993年 / 15卷 / 01期
关键词：
D O I：
10.3109/08860229309065567
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
The angiotensin I-converting enzyme (ACE) activity was measured in urine, serum, and tissues from rats with carbon tetrachloride (CCl4)-induced acute renal failure on days 1, 2, 3, and 7 after CCl4 administration. Serum ACE increased on days 1 to 3. Heart, lung, small intestine, brain, and testis ACE decreased, whereas kidney and liver ACE remained unchanged. Urine ACE activity increased from day 1 to day 3. Our data suggest that the increase in serum ACE may be secondary to the ACE release from the damaged tissues, and that the urine ACE increase may be due to the kidney proximal tubule damage. This work supports the contention that an increase in urine ACE may be an indicator of damage to the proximal tubule.
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收藏
页码：19 / 26
页数：8
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