RECOMBINANT LD78 PROTEIN, A MEMBER OF THE SMALL CYTOKINE FAMILY, ENHANCES OSTEOCLAST DIFFERENTIATION IN RAT BONE-MARROW CULTURE SYSTEM

被引：17
作者：
KUKITA, T
NAKAO, J
HAMADA, F
KUKITA, A
INAI, T
KURISU, K
NOMIYAMA, H
机构：
[1] CHEMO SERO THERAPEUT RES INST, KIKUCHI LAB, MOLEC GENET LAB, KIKUCHI, KUMAMOTO, JAPAN
[2] KUMAMOTO UNIV, SCH MED, DEPT BIOCHEM, KUMAMOTO 860, JAPAN
来源：
BONE AND MINERAL | 1992年 / 19卷 / 03期
关键词：
RECOMBINANT-LD78; SMALL INDUCIBLE PROTEIN FAMILY; DIFFERENTIATION OF OSTEOCLASTS;
D O I：
10.1016/0169-6009(92)90871-A
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Cytokine LD78 is a member of the small inducible protein family involved in cell growth, wound healing and inflammation. However, its exact function is not known. In this study, we demonstrated that recombinant LD78alpha and its variant LD78beta proteins stimulate osteoclast-like cell formation in rat bone marrow cultures in the presence of 1alpha,25-dihydroxyvitamin D3. This enhancing activity was independent of prostaglandin synthesis. This is the first report which describes the effect of proteins involved in the small inducible protein family on the differentiation of osteoclasts.
引用
收藏
页码：215 / 223
页数：9
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