2 NOVEL, POTENT AND SELECTIVE HISTAMINE H-3 RECEPTOR AGONISTS

被引：41

作者：

HOWSON, W

PARSONS, ME

RAVAL, P

SWAYNE, GTG

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT LTD,WELWYN GARDEN CIT AL6 9AR,HERTS,ENGLAND

[2] PFIZER LTD,SANDWICH C213 9NJ,KENT,ENGLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(00)80659-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

S-[2-(4-(5)-imidazoyl)ethyl]isothiourea (1) and 4-(4-(5)-imidazoyl)butyramidine (2) were shown to be potent H-3 agonists on the guinea-pig ileum with very little activity on H-1 and H-2 receptor preparations.

引用

页码：77 / 78

页数：2

共 10 条

[1] AUTO-INHIBITION OF BRAIN HISTAMINE-RELEASE MEDIATED BY A NOVEL CLASS (H-3) OF HISTAMINE-RECEPTOR [J].

ARRANG, JM ;

GARBARG, M ;

SCHWARTZ, JC .

NATURE, 1983, 302 (5911) :832-837

[2] HIGHLY POTENT AND SELECTIVE LIGANDS FOR HISTAMINE RECEPTORS-H-3 [J].

ARRANG, JM ;

GARBARG, M ;

LANCELOT, JC ;

LECOMTE, JM ;

POLLARD, H ;

ROBBA, M ;

SCHUNACK, W ;

SCHWARTZ, JC .

NATURE, 1987, 327 (6118) :117-123

[3]

ARRANG JM, 1966, Patent No. 197840

[4]

ARRANG JM, 1987, Patent No. 214058

[5] RECEPTORS MEDIATING SOME ACTIONS OF HISTAMINE [J].

ASH, ASF ;

SCHILD, HO .

BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1966, 27 (02) :427-&

[6] DEFINITION AND ANTAGONISM OF HISTAMINE H2-RECEPTORS [J].

BLACK, JW ;

PARSONS, EM ;

DURANT, CJ ;

DUNCAN, WAM ;

GANELLIN, CR .

NATURE, 1972, 236 (5347) :385-&

[7]

BLACK JW, 1976, Patent No. 3954982

[8]

BLACK JW, 1973, Patent No. 3759994

[9] DIMAPRIT - [S-[3-(N,N-DIMETHYLAMINO)PROPYL]ISOTHIOUREA] - HIGHLY SPECIFIC HISTAMINE H2-RECEPTOR AGONIST .1. PHARMACOLOGY [J].

PARSONS, ME ;

OWEN, DAA ;

GANELLIN, CR ;

DURANT, GJ .

AGENTS AND ACTIONS, 1977, 7 (01) :31-37

[10]

TRZECIAKOWSKI JP, 1987, J PHARMACOL EXP THER, V243, P874

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