METABOLIC PRODUCTS OF ASPERGILLUS-TERREUS .10. BIOSYNTHESIS OF ASTERRIQUINONES

被引：40

作者：

ARAI, K

YAMAMOTO, Y

机构：

[1] Faculty Of Pharmaceutical Sciences, Kanazawa University, Kanazawa 920

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1990年 / 38卷 / 11期

关键词：

Asperigillus terreus; asterriquinone; asterriquinone synthase; biosynthesis; methyltransferase; prenyltransfease;

D O I：

10.1248/cpb.38.2929

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The biosynthesis of asterriquinones in Aspergillus terreus var. africanus IFO 8835 has been elucidated. Enzymatic activities for the formation of demethyl asterriquinone-D (asterriquinone synthase), prenyltransferase and methyltransferase on asterriquinone were detected in a crude extract of mycelium. Demethyl asterriquinone is biosynthesized from indolepyruvic acid and then methylation of the hydroxyl of group of the quinone moiety occurs. Prenylation proceeds simultaneously at the C-7, C-2 and N-l positions of the indole moiety. © 1990, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：2929 / 2932

页数：4

共 24 条

[1] BIOSYNTHESIS OF ECHINULIN ISOPRENYLATION OF CYCLO-L-ALANYL-L-TRYPTOPHANYL [J].