IRREVERSIBLE ENZYME INHIBITORS .166. ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 2,4-DIAMINO-5-(3,4-DICHLOROPHENYL)PYRIMIDINE WITH 6 SUBSTITUENTS AND SOME FACTORS IN THEIR CELL WALL TRANSPORT

被引：10

作者：

BAKER, BR

VERMEULE.NM

机构：

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1970年 / 13卷 / 01期

关键词：

D O I：

10.1021/jm00295a021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：82 / &

共 17 条

[1] IRREVERSIBLE ENZYME INHIBITORS .160. SOME FACTORS IN CELL WALL TRANSPORT OF ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITORS OF DIHYDROFOLIC REDUCTASE DERIVED FROM 4,6-DIAMINO-1,2-DIHYDRO-2,2-DIMETHYL-L-(PHENYLALKYLPHENYL)-S-TRIAZINES [J].

BAKER, BR ;

JANSON, EE ;

VERMEULEN, NM .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (05) :898-+

[2] IRREVERSIBLE ENZYME INHIBITORS .165. PROTEOLYTIC ENZYMES .15. INHIBITION OF GUINEA PIG COMPLEMENT BY DERIVATIVES OF M-PHENOXYPROPOXYBENZAMIDINE [J].

BAKER, BR ;

CORY, M .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (06) :1053-&

[3] IRREVERSIBLE ENZYME INHIBITORS .158. EFFECT OF BRIDGE MODIFICATION ON SELECTIVE IRREVERSIBLE INHIBITION OF DIHYDROFOLIC REDUCTASE FROM L1210 MOUSE LEUKEMIA AND LIVER BY 2,4-DIAMINO-5-(3,4-DICHLOROPHENYL)-6-[P-(M-FLUOROSULFONYLBENZAMIDOMETHYL)PHENOXYMETHYL]PYRIMIDINE .2. [J].

BAKER, BR ;

VERMEULEN, NM .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (04) :684-+

[4]

BAKER BR, 1969, J MED CHEM, V12, P680, DOI 10.1021/jm00304a027

[5]

BAKER BR, 1969, J MED CHEM, V12, P89, DOI 10.1021/jm00301a023

[6] IRREVERSIBLE ENZYME INHIBITORS . 136 . 2,4- DIAMINO-5-(3,4-DICHLOROPHENYL)-6-(P-(M-FLUOROSULFONYLBENZAMIDO)PHENOXYMETHYL)PYRIMIDINE AN ACTIVE-SITE-DIRECTED IRREVERSIBLE INHIBITOR OF DIHYDROFOLIC REDUCTASE . EFFECT OF STRUCTURE ON ISOZYME SPECIFICITY [J].

BAKER, BR ;

VERMEULEN, NM .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (01) :82-+

[7]

BAKER BR, 1969, J MED CHEM, V12, P74, DOI 10.1021/jm00301a019

[8] IRREVERSIBLE ENZYME INHIBITORS . 133 . STUDIES ON DIFFERENTIAL IRREVERSIBLE INHIBITION OF DIHYDROFOLIC REDUCTASE FROM 3 STRAINS OF L1210 LEUKEMIA LIVER SPLEEN AND INTESTINE OF MOUSE [J].

BAKER, BR ;

LOURENS, GJ ;

MEYER, RB ;

VERMEULEN, NM .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (01) :67-+

[9]

BAKER BR, 1968, J MED CHEM, V11, P475, DOI 10.1021/jm00309a015

[10] IRREVERSIBLE ENZYME INHIBITORS . 135 . EFFECT OF RING SUBSTITUTION ON SELECTIVE IRREVERSIBLE INHIBITION OF DIHYDROFOLIC REDUCTASE FROM L1210 MOUSE LEUKEMIA AND LIVER BY 2,4-DIAMINO-5-(3,4-DICHLOROPHENYL)-6-(P-(P-FLUOROSULFONYLPHENYLUREIDO)PHENOXYMETHYL)PYRIMIDINE [J].

BAKER, BR ;

VERMEULEN, NM .

JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (01) :79-+

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