A NEW CYTO-TOXIC, DNA INTERSTRAND CROSSLINKING AGENT, 5-(AZIRIDIN-1-YL)-4-HYDROXYLAMINO-2-NITROBENZAMIDE, IS FORMED FROM 5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE (CB-1954) BY A NITROREDUCTASE ENZYME IN WALKER CARCINOMA-CELLS

被引:151
作者
KNOX, RJ
FRIEDLOS, F
JARMAN, M
ROBERTS, JJ
机构
[1] INST CANC RES,MOLEC PHARMACOL UNIT,BLOCK F,COTSWOLD RD,SUTTON SM2 5NG,SURREY,ENGLAND
[2] INST CANC RES,CHEM DRUG METAB TEAM,DRUG DEV SECT,SUTTON SM2 5NG,SURREY,ENGLAND
关键词
D O I
10.1016/0006-2952(88)90335-8
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:4661 / 4669
页数:9
相关论文
共 29 条
[1]   ANTIBODY DIRECTED ENZYMES REVIVE ANTICANCER PRODRUGS CONCEPT [J].
BAGSHAWE, KD .
BRITISH JOURNAL OF CANCER, 1987, 56 (05) :531-532
[2]  
BARKER WC, 1984, PROTEIN IDENTIFICATI
[3]   RAT-LIVER NAD(P)H-QUINONE REDUCTASE - ISOLATION OF A QUINONE REDUCTASE STRUCTURAL GENE AND PREDICTION OF THE NH2 TERMINAL SEQUENCE OF THE PROTEIN BY DOUBLE-STRANDED SEQUENCING OF EXONS 1 AND 2 [J].
BAYNEY, RM ;
PICKETT, CB .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1988, 260 (02) :847-850
[4]  
BAYNEY RM, 1987, J BIOL CHEM, V262, P572
[5]   ARYLHYDROXYLAMINES .4. THEIR COLORIMETRIC DETERMINATION [J].
BOYLAND, E ;
NERY, R .
ANALYST, 1964, 89 (105) :95-&
[6]   2,4-DINITRO-5-ETHYLENEIMINOBENZAMIDE (CB 1954) - A POTENT AND SELECTIVE INHIBITOR OF GROWTH OF WALKER CARCINOMA 256 [J].
COBB, LM ;
CONNORS, TA ;
ELSON, LA ;
KHAN, AH ;
MITCHLEY, BC ;
ROSS, WCJ ;
WHISSON, ME .
BIOCHEMICAL PHARMACOLOGY, 1969, 18 (06) :1519-&
[7]   STUDIES ON REVERSAL OF SELECTIVE ANTITUMOR EFFECT OF AZIRIDINYL DERIVATIVE CB 1954 BY 4-AMINO-5-IMIDAZOLECARBOXAMIDE [J].
CONNORS, TA ;
MANDEL, HG ;
MELZACK, DH .
INTERNATIONAL JOURNAL OF CANCER, 1972, 9 (01) :126-&
[8]   STUDIES ON MECHANISM OF ACTION OF 5-AZIRIDINYL-2,4-DINITROBENZAMIDE (CB 1954), A SELECTIVE INHIBITOR OF WALKER TUMOUR [J].
CONNORS, TA ;
MELZACK, DH .
INTERNATIONAL JOURNAL OF CANCER, 1971, 7 (01) :86-&
[9]  
DEBAUN JR, 1970, CANCER RES, V30, P577
[10]  
ERNSTER L, 1987, CHEM SCRIPTA, V27A, P1