Membranous glomerulonephritis associated with Mycobacterium shimoidei pulmonary infection

被引:14
作者
Kanaji, Nobuhiro [1 ]
Kushida, Yoshio [2 ]
Bandoh, Shuji [1 ]
Ishii, Tomoya [1 ]
Haba, Reiji [2 ]
Tadokoro, Akira [1 ]
Watanabe, Naoki [1 ]
Takahama, Takayuki [1 ]
Kita, Nobuyuki [1 ]
Dobashi, Hiroaki [1 ]
Matsunaga, Takuya [1 ]
机构
[1] Kagawa Univ, Fac Med, Dept Internal Med, Div Endocrinol & Metab Hematol Rheumatol & Resp, Kagawa, Japan
[2] Kagawa Univ, Fac Med, Dept Diagnost Pathol, Kagawa, Japan
关键词
non-tuberculous; mycobacterium; shimoidei; membranous glomerulonephritis; proteinuria;
D O I
10.12659/AJCR.889684
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Membranous glomerulonephritis can occur secondarily from infectious diseases. There are no reports describing membranous glomerulonephritis caused by non-tuberculous mycobacterium infection. However, several cases with membranous glomerulonephritis due to Mycobacterium tuberculosis have been reported. Mycobacterium shimoidei is an uncommon pathogen, and less than 20 cases with this species have been reported. A therapeutic regimen for this infection has not been established yet. Case Report: An 83-year-old Japanese man presented with productive cough for 6 months. Computed tomography scan showed multiple cavities in the bilateral pulmonary fields. Acid-fast bacilli were evident in his sputum by Ziehl-Neelsen staining (Gaffky 3). PCR amplifications for Mycobacterium tuberculosis, Mycobacterium avium, and Mycobacterium intracellulare were all negative. Finally, Mycobacterium shimoidei was identified by rpoB sequencing and 16S rRNA sequencing. Urine examination showed a sub-nephrotic range of proteinuria and histology of the kidney showed membranous glomerulonephritis. Antimycobacterial treatment with clarithromycin, rifampicin, and ethambutol dramatically improved not only the pulmonary disease, but also the proteinuria. Conclusions: To the best of our knowledge, the presented case is the first report showing non-tuberculous mycobacteriuminduced secondary membranous glomerulonephritis. A combination with clarithromycin, ethambutol, and rifampicin might be effective for treatment of Mycobacterium shimoidei infection.
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页码:543 / 547
页数:5
相关论文
共 29 条
[1]  
Auregan G, 1997, B SOC PATHOL EXOT, V90, P75
[2]  
Chomyc SA, 1991, CDWR, V17, P85
[3]   Collapsing Glomerulopathy in a 16-year-old girl with pulmonary tuberculosis: The role of systemic inflammatory mediators [J].
Coventry, S ;
Shoemaker, LR .
PEDIATRIC AND DEVELOPMENTAL PATHOLOGY, 2004, 7 (02) :166-170
[4]  
FURRER H, 1994, SCHWEIZ MED WSCHR, V124, P89
[5]   An Australian isolate of Mycobacterium shimoidei [J].
Goudge, RJ ;
Mayall, BC ;
Leslie, DE ;
Holmes, PW ;
Robinson, SL .
PATHOLOGY, 1998, 30 (04) :399-401
[6]   An official ATS/IDSA statement: Diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases [J].
Griffith, David E. ;
Aksamit, Timothy ;
Brown-Elliott, Barbara A. ;
Catanzaro, Antonino ;
Daley, Charles ;
Gordin, Fred ;
Holland, Steven M. ;
Horsburgh, Robert ;
Huitt, Gwen ;
Iademarco, Michael F. ;
Iseman, Michael ;
Olivier, Kenneth ;
Ruoss, Stephen ;
von Reyn, C. Fordham ;
Wallace, Richard J., Jr. ;
Winthrop, Kevin .
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2007, 175 (04) :367-416
[7]   Identification of Mycobacterium shimoidei in a tuberculosis-like cavity by 16S ribosomal DNA direct sequencing [J].
Heller, R ;
Jaulhac, B ;
Charles, P ;
DeBriel, D ;
Vincent, V ;
Bohner, C ;
Piemont, Y ;
Monteil, H .
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1996, 15 (02) :172-175
[8]  
HOGG RJ, 1985, J PEDIATR-US, V106, P571
[9]  
HONIG C, 1980, LAB INVEST, V42, P427
[10]  
Iimura Osamu, 2003, Nihon Jinzo Gakkai Shi, V45, P439