Carbapenem resistance: overview of the problem and future perspectives

被引：483

作者：

Meletis, Georgios ^{[1
]}

机构：

[1] Labnet Labs, Agiou Dimitriou Str 161, Thessaloniki 53337, Greece

来源：

THERAPEUTIC ADVANCES IN INFECTIOUS DISEASE | 2016年 / 3卷 / 01期

关键词：

antibiotic resistance; carbapenemases; carbapenems;

D O I：

10.1177/2049936115621709

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Carbapenem resistance, mainly among Gram-negative pathogens, is an ongoing public-health problem of global dimensions. This type of antimicrobial resistance, especially when mediated by transferable carbapenemase-encoding genes, is spreading rapidly causing serious outbreaks and dramatically limiting treatment options. In this article, important key points related to carbapenem resistance are reviewed and future perspectives are discussed.

引用

页码：15 / 21

页数：7

共 62 条

[1] Higher Incidence of Acute Kidney Injury With Intravenous Colistimethate Sodium Compared With Polymyxin B in Critically Ill Patients at a Tertiary Care Medical Center [J].

Akajagbor, Darowan S. ;

Wilson, Sharon L. ;

Shere-Wolfe, Kapana D. ;

Dakum, Paul ;

Charurat, Manhattan E. ;

Gilliam, Bruce L. .

CLINICAL INFECTIOUS DISEASES, 2013, 57 (09) :1300-1303

[2] THE STRUCTURE OF BETA-LACTAMASES [J].

AMBLER, RP .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1980, 289 (1036) :321-331

[3] Mechanisms of multidrug resistance in Acinetobacter species and Pseudomonas aeruginosa [J].

Bonomo, Robert A. ;

Szabo, Dora .

CLINICAL INFECTIOUS DISEASES, 2006, 43 :S49-S56

[4] Biochemical Characterization of the POM-1 Metallo-β-Lactamase from Pseudomonas otitidis [J].

Borgianni, Luisa ;

De Luca, Filomena ;

Thaller, Maria Cristina ;

Chong, Yunsop ;

Rossolini, Gian Maria ;

Docquier, Jean-Denis .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (03) :1760-1763

[5] Spread of OXA-48-Positive carbapenem-resistant Klebsiella pneumoniae isolates in Istanbul, Turkey [J].

Carrer, Amelie ;

Poirel, Laurent ;

Eraksoy, Haluk ;

Cagatay, A. Atahan ;

Badur, Selim ;

Nordmann, Patrice .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (08) :2950-2954

[6] Spread of OXA-48-Encoding Plasmid in Turkey and Beyond [J].

Carrer, Amelie ;

Poirel, Laurent ;

Yilmaz, Mesut ;

Akan, Oezay Arikan ;

Feriha, Cilli ;

Cuzon, Gaelle ;

Matar, Ghassan ;

Honderlick, Patrick ;

Nordmann, Patrice .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (03) :1369-1373

[7] Molecular characterization of a β-lactamase gene, blaGIM-1, encoding a new subclass of metallo-β-lactamase [J].

Castanheira, M ;

Toleman, MA ;

Jones, RN ;

Schmidt, FJ ;

Walsh, TR .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2004, 48 (12) :4654-4661

[8] Early Dissemination of NDM-1-and OXA-181-Producing Enterobacteriaceae in Indian Hospitals: Report from the SENTRY Antimicrobial Surveillance Program, 2006-2007 [J].

Castanheira, Mariana ;

Deshpande, Lalitagauri M. ;

Mathai, Dilip ;

Bell, Jan M. ;

Jones, Ronald N. ;

Mendes, Rodrigo E. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (03) :1274-1278

[9]

CDC, 2013, ANTIBIOTIC RESISTANC

[10] Plasmid-mediated carbapenem-hydrolysing OXA-48 β-lactamase in Klebsiella pneumoniae from Tunisia [J].

Cuzon, Gaelle ;

Naas, Thierry ;

Lesenne, Aude ;

Benhamou, Michel ;

Nordmann, Patrice .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2010, 36 (01) :91-93

← 1 2 3 4 5 6 7 →