THE PATHOPHYSIOLOGY OF PNEUMOCOCCAL MENINGITIS

被引：21

作者：

SPELLERBERG, B ^{[1
]}

TUOMANEN, EI ^{[1
]}

机构：

[1] ROCKEFELLER UNIV, MOLEC INFECT DIS LAB, NEW YORK, NY 10021 USA

来源：

ANNALS OF MEDICINE | 1994年 / 26卷 / 06期

关键词：

PNEUMOCOCCUS; MENINGITIS; CELL WALL; CYTOKINES; ANTIINFLAMMATORY THERAPY; ANTIBIOTIC RESISTANCE;

D O I：

10.3109/07853899409148362

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The interactions between pneumoccocal surface components and host defence systems that initiate pneumoccocal meningitis have been studied in considerable molecular detail over the past decade. In this sense, the pneumococcus has served as a prototype for the unravelling of the genesis of inflammation caused by gram-positive bacteria. This review outlines the progression of these early events involving the cytokine cascade, the coagulation cascade, and leukocyte migration, and relates these processes to the production of blood-brain barrier permeability, the hallmark of injury in meningitis. This new understanding has radically altered the therapy of disease with the promise of greatly improved outcome.

引用

页码：411 / 418

页数：8

共 78 条

[1] IDENTIFICATION OF AN ACTIVE DISACCHARIDE UNIT OF A GLYCOCONJUGATE RECEPTOR FOR PNEUMOCOCCI ATTACHING TO HUMAN PHARYNGEAL EPITHELIAL-CELLS [J].