DIRECT DETERMINATION OF PROTON-EXCHANGE KINETICS BY 320-MHZ TRITIUM NMR-SPECTROSCOPY

被引：17

作者：

DIXON, RE

WILLIAMS, PG

SALJOUGHIAN, M

LONG, MA

STREITWIESER, A

机构：

[1] UNIV CALIF BERKELEY,LAWRENCE BERKELEY LAB 75-123,NATL TRITIUM LABELING FACIL,BERKELEY,CA 94720

[2] UNIV CALIF BERKELEY,DEPT CHEM,BERKELEY,CA 94720

[3] UNIV NEW S WALES,SCH CHEM,KENSINGTON,NSW 2033,AUSTRALIA

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 1991年 / 29卷 / 05期

关键词：

H-3; NMR; EXCHANGE RATES; KINETIC ACIDITY; KINETICS;

D O I：

10.1002/mrc.1260290517

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first application of tritium NMR spectroscopy to the direct observation of proton-exchange kinetics is described; this technique allows the study of milligram amounts of substrates and for substrates with multiple exchangeable positions. The examples include benzene and the ring and methyl positions of p-xylene reacting with cesium cyclohexylamide in cyclohexylamine, and the enolate positions of cyclohexanone and methyl 7,12-dihydroxy-3-ketocholan-24-oate reacting with heptafluorobutyric acid in dioxane.

引用

页码：509 / 512

页数：4