Selected nutritional and immunological indices of 118 patients with methicillin-resistant Staphylococcus aureus (MRSA) were reviewed retrospectively. Those patients with nosocomial infections had significantly (P < .05) lower levels of serum albumin, total protein, absolute lymphocyte, and percentage of lymphocytes (on differential) than all others (ie, community-acquired infections and colonizations and nosocomial colonizations). Therefore, these parameters might be important indicators of subsequent MRSA infestation in certain patient populations.