SYNTHESES WITH STABLE ISOTOPES - THYMINE-2,6-C-13(2)

被引：8

作者：

REDWINE, CM

WHALEY, TW

机构：

[1] Organic and Biochemical Synthesis Group, Los Alamos Scientific Laboratory (MS890), University of California, Los Alamos, New Mexico

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1979年 / 16卷 / 02期

关键词：

Carbon‐13; Hydrogenation; Thymine‐2,6‐[!sup]13[!/sup]C[!sub]2[!/sub; α‐Cyano‐[!sup]13[!/sup]C‐propionylurea‐[!sup]13[!/sup]C;

D O I：

10.1002/jlcr.2580160211

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A three‐step synthesis of thymlne‐2,6‐13C2 from urea‐13C, sodium cyanide‐13C, and α‐bromopropionic acid is described. The last reaction involves hydrogenation of α‐cyano‐13C‐propionylurea‐13C in aqueous acetic acid and produces thymine‐2,6‐13C2 in 50–60% yield. The mechanism of this reaction is discussed. Copyright © 1979 John Wiley & Sons, Ltd.

引用

页码：315 / 320

页数：6