ENHANCEMENT OF A23187-INDUCED RELEASE OF ENTERIC VASOACTIVE INTESTINAL POLYPEPTIDE BY PHORBOL 12,13-DIBUTYRATE

被引：3

作者：

BELAI, A

DALE, MM

BURNSTOCK, G

机构：

[1] UNIV LONDON UNIV COLL,DEPT ANAT & DEV BIOL,GOWER ST,LONDON WC1E 6BT,ENGLAND

[2] UNIV LONDON UNIV COLL,CTR NEUROSCI,LONDON WC1E 6BT,ENGLAND

[3] UNIV LONDON UNIV COLL,DEPT PHARMACOL,LONDON WC1E 6BT,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 177卷 / 1-2期

基金：

英国惠康基金;

关键词：

Enteric nerves; Phorbol 12,13-dibytyrate; Vasoactive intestinal polypeptide (VIP);

D O I：

10.1016/0014-2999(90)90557-M

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of phorbol 12,13-dibutyrate on calcium ionophore (A23187)-induced release of vasoactive intestinal polypeptide from enteric nerves was examined. A23187 caused release of vasoactive intestinal polypeptide dose dependently and phorbol 12,13-dibutyrate (100 nM) markedly shifted the dose-response curve of A23187 to the left. The significance of these findings will be discussed in relation to the mechanism of release of vasoactive intestinal polypeptide from enteric nerves. © 1990.

引用

页码：103 / 105

页数：3

共 10 条

[1] VIP RELEASE FROM ENTERIC NERVES IS INDEPENDENT OF EXTRACELLULAR CALCIUM [J].