ROLE OF ACIDOSIS IN RENAL OSTEOMALACIA

被引：39

作者：

COCHRAN, M

NORDIN, BEC

机构：

[1] Medical Research Council, Mineral Metabolism Research Unit, General Infirmary, Leeds

来源：

BRITISH MEDICAL JOURNAL | 1969年 / 2卷 / 5652期

关键词：

D O I：

10.1136/bmj.2.5652.276

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Of nine patients with uraemic osteomalacia, the underlying renal lesion was pyelonephritis in seven. All of the patients were characterized by impairment of acidifying power and severe metabolic acidosis. It is suggested that metabolic acidosis may be a definite factor in the pathogenesis of uraemic osteomalacia, possibly by reducing the proportion of trivalent phosphate in the plasma and/or by reducing plasma calcium. © 1969, British Medical Journal Publishing Group. All rights reserved.

引用

页码：276 / &

共 29 条

[11]

HIOCO DJ, 1967, OSTEOMALACIE ED, P3

[12]

Holt LE, 1925, J BIOL CHEM, V64, P509

[13]

JOPLIN GF, 1967, OSTEOMALACIE, P249

[14]

KNOWLES F., 1968, J MED LAB TECHNOL, V25, P130

[15] STUDIES OF MECHANISM BY WHICH CHRONIC METABOLIC ACIDOSIS AUGMENTS URINARY CALCIUM EXCRETION IN MAN [J].