SIMULTANEOUS ADMINISTRATION OF IN-111-HUMAN IMMUNOGLOBULIN AND TC-99M-HMPAO LABELED LEUKOCYTES IN INFLAMMATORY BOWEL-DISEASE

被引:29
作者
MAIRAL, L
DELIMA, PA
MARTINCOMIN, J
BALIELLAS, C
XIOL, X
ROCA, M
RICART, Y
RAMOS, M
机构
[1] CSUB,HOSP PRINCEPS ESPANYA,DEPT NUCL MED,E-08907 LHOSPITALET LLOBR,SPAIN
[2] CONSELHO NACL DESENVOLVIMENTO CIENT & TECNOL,RIO JANEIRO,BRAZIL
[3] CSUB,HOSP PRINCEPS ESPANYA,DEPT GASTROENTEROL,E-08907 LHOSPITALET LLOBR,SPAIN
来源
EUROPEAN JOURNAL OF NUCLEAR MEDICINE | 1995年 / 22卷 / 07期
关键词
TC-99M HEXAMETHYLPROPYLENE AMINE OXIME; LABELED LEUKOCYTES; IN-111; IMMUNOGLOBULIN; INFLAMMATORY BOWEL DISEASE; DUAL TRACER STUDIES;
D O I
10.1007/BF01254568
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Technetium-99m hexamethylpropylene amine oxime (HMPAO) labelled leucocytes and indium-111 polyclonal immunoglobulin (IgG) were simultaneously injected into a group of 27 patients routinely referred for the investigation of inflammatory bowel disease (IBD). Ten-minute anterior abdomen and tail on detector views were obtained at 30 min, 4 h and 24 h p.i. of both tracers. The diagnosis of IBD was obtained in all cases by endoscopy with biopsy and/or surgery. Images were blindly evaluated by two experienced observers who only knew of the clinical suspicion of IBD. IBD was confirmed in 20 patients (12 with Crohn's disease and eight with ulcerative colitis). Sensitivity, specificity and accuracy were 100%, 85% and 96% respectively for labelled leucocytes and 70%, 85% and 74% for IgG. Both IgG and leucocyte scans were normal in six out of seven patients in whom a diagnosis of IBD was excluded; the remaining patient, with ischaemic colitis, was falsely positive with both agents. As far as disease extension is concerned, the IgG study localized 27 diseased segments, whereas 49 were seen with the leucocyte study. Eighty-four segments were normal and 25 showed tracer uptake with both agents, Twenty-four were positive only with the leucocyte study and two were positive only with the IgG study. Agreement between the agents was 80.7%. These results confirm that In-111-human polyclonal scintigraphy is less sensitive than Tc-99m-HMPAO scintigraphy both for the diagnosis of IBD and in the evaluation of disease extension. Nevertheless, if leucocyte labelling is not available, labelled IgG can be used only for diagnostic purposes.
引用
收藏
页码:664 / 670
页数:7
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