A STRONG NEGATIVE ASSOCIATION BETWEEN ALCOHOL-CONSUMPTION AND THE RISK OF HEPATOCELLULAR-CARCINOMA IN CIRRHOTIC-PATIENTS - A CASE-CONTROL STUDY

被引：15

作者：

ARICO, S

CORRAO, G

TORCHIO, P

GALATOLA, G

TABONE, M

VALENTI, M

DIORIO, F

机构：

[1] Divisione di Gastroenterologia, Ospedale Mauriziano Umberto I, Torino, I-10128

[2] Institute of Statistical and Mathematical Sciences, University of Milan, Milan

[3] Department of Internal Medicine and Public Health, Epidemiology Research Center, School of Medicine, University of Aquila, Aquila

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 1994年 / 10卷 / 03期

关键词：

ALCOHOL CONSUMPTION; CASE-CONTROL STUDY; HBV INFECTION; HEPATOCELLULAR CARCINOMA; LIVER CIRRHOSIS;

D O I：

10.1007/BF01719346

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

We carried out a hospital-based, case-control study to assess the association of both the Hepatitis B Virus (HBV) infection and the lifetime daily alcohol intake with the risk of developing hepatocellular carcinoma (HCC) in patients with liver cirrhosis (LC). Cases were 62 consecutive inpatients of a Gastroenterology Division in whom a first diagnosis of HCC superimposed on LC was made. Two control groups were used: 310 patients without liver disease, matched 1:5 with cases and randomly selected from inpatients of the same hospital, and 97 consecutive asymptomatic inpatients in whom the first diagnosis of LC was made. Alcohol intake was quantified in all subjects by a standardized questionnaire. HBV infection was associated with WCC development in cirrhotics (odds ratio = 6.8; 95% confidence interval = 1.4 - 32.3), whereas we observed a trend towards a decreased HCC risk at increased alcohol intake values (odds ratio from 1 for lifetime abstainers to 0.2 for drinkers of 175 g/day or more). Our results suggest that alcohol intake is not a direct determinant of HCC, but its role is mediated by LC. Cirrhotics with high alcohol intake do not usually survive long enough to develop HCC.

引用

页码：251 / 257

页数：7

共 41 条

[1]

Beasly R.P., Hwang L.Y., Epidemiology of hepatocellular carcinoma, Viral hepatitis and liver disease, pp. 209-224, (1984)

[2]

Popper H., Shafritz D.A., Hoofnagle J.H., Relation of the hepatitis B carrier state to hepatocellular carcinoma, Hepatology, 7, pp. 764-772, (1987)

[3]

Szmuness W., Hepatocellular carcinoma and the hepatitis B virus: Evidence for a causal association, Prog Med Virol, 24, pp. 40-69, (1978)

[4]

Bruix J., Barrera J.M., Calvet X., Et al., Lancet, pp. 1004-1006, (1989)

[5]

Chiaramonte M., Farinati F., Fagiuoli S., Et al., Lancet, pp. 301-302, (1990)

[6]

Viranuvatti V., Daongsak C., Chainuvat T., Carcinoma of the liver in Thailand: Trends in two decades, Ann Acad Med, 9, pp. 196-198, (1980)

[7]

Naccarato R., Farinati F., Hepatocellular carcinoma, alcohol and cirrhosis: Facts and hypothesis, Dig Dis Sci, 36, pp. 1137-1142, (1991)

[8]

Hakulinen T., Lehtinamaki L., Lehtonen M., Cancer morbidity among two male cohorts with increased alcoholic consumption in Finland, J Nat Canc Inst, 52, pp. 1711-1714, (1974)

[9]

Jensen O.M., Cancer morbidity and causes of death among Danish brewery workers, Int J Cane, 23, pp. 454-463, (1979)

[10]

Pagliaro L., Simonetti R.G., Craxi A., Alcohol and HBV infection as risk factors for hepatocellular carcinoma in Italy: A multicentric controlled study, Hepatogastroenterol, 30, pp. 48-50, (1983)

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