RELATIONSHIP OF CLEAR-CELL ONCOCYTOMA TO MITOCHONDRIAL-RICH (TYPICAL) ONCOCYTOMAS OF PAROTID SALIVARY-GLAND - AN ULTRASTRUCTURAL-STUDY

被引:16
作者
DAVY, CL
DARDICK, I
HAMMOND, E
THOMAS, MJ
机构
[1] UNIV TORONTO, BANTING INST, DEPT PATHOL, ROOM 072, 100 COLL ST, TORONTO M5G 1L5, ONTARIO, CANADA
[2] CANADIAN REFERENCE CTR CANC PATHOL, OTTAWA, ON, CANADA
[3] LDS HOSP, DEPT PATHOL, SALT LAKE CITY, UT USA
[4] BUTTERWORTH HOSP, DEPT PATHOL, GRAND RAPIDS, MI USA
来源
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY | 1994年 / 77卷 / 05期
关键词
D O I
10.1016/0030-4220(94)90226-7
中图分类号
R78 [口腔科学];
学科分类号
1003 ;
摘要
Nosologically, the designation clear cell oncocytoma seems illogical and contradictory when the definition of an oncocytoma relies on mitochondrial-rich cells; its relationship to the granular (mitochondrial-rich) oncocytoma needs further clarification. Electron microscopy of six examples of oncocytoma from five patients allowed assessment of cellular features in three clear cell variants, two typical oncocytomas and one with a roughly equal proportion of clear and granular tumor cells. Ultrastructurally, in the clear cell types of oncocytoma, a considerable to extensive portion of the central cytoplasm was occupied by monoparticulate glycogen with margination of mitochondria and other organelles. The degree of extraction of the glycogen during fixation and processing accounts for variation in the extent of the clear cell component as phosphotungstic acid-hematoxylin staining reveals considerable mitochondria in many of the tumor cells in the clear cell variant of oncocytoma. Ultrastructural findings further support an interrelationship between clear and granular cells, as some typical oncocytes are evident in the dear cell variant of oncocytoma, and one oncocytoma in this series had a roughly equal number of glycogen-rich and mitochondrial-rich tumor cells both of which took part in the formation of microlumens. The designation clear cell oncocytoma is appropriate within the oncocytoma subgroup of salivary gland tumors.
引用
收藏
页码:469 / 479
页数:11
相关论文
共 30 条
  • [1] ASKEW JB, 1971, ARCHIV OTOLARYNGOL, V93, P46
  • [2] BLANCK C, 1970, CANCER-AM CANCER SOC, V25, P919, DOI 10.1002/1097-0142(197004)25:4<919::AID-CNCR2820250427>3.0.CO
  • [3] 2-7
  • [4] ONCOCYTIC TUMORS OF MAJOR SALIVARY-GLANDS - A STUDY OF 68 CASES WITH FOLLOW-UP OF 44 PATIENTS
    BRANDWEIN, MS
    HUVOS, AG
    [J]. AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1991, 15 (06) : 514 - 528
  • [5] CARLSOO B, 1979, ARCH PATHOL LAB MED, V103, P471
  • [6] CHANG A, 1992, PATHOL ANNU, V27, P263
  • [7] CUTLER LS, 1977, ARCH PATHOL LAB MED, V101, P420
  • [8] WARTHIN TUMOR - AN ULTRASTRUCTURAL AND IMMUNOHISTOCHEMICAL STUDY OF BASILAR EPITHELIUM
    DARDICK, I
    CLAUDE, A
    PARKS, WR
    HOPPE, D
    STINSON, J
    BURNS, BF
    LITTLE, J
    BROWN, DL
    DAIRKEE, SH
    [J]. ULTRASTRUCTURAL PATHOLOGY, 1988, 12 (04) : 419 - 432
  • [9] PROCEDURAL GUIDE TO SPECIMEN HANDLING FOR THE ULTRASTRUCTURAL PATHOLOGY SERVICE LABORATORY
    DVORAK, AM
    [J]. JOURNAL OF ELECTRON MICROSCOPY TECHNIQUE, 1987, 6 (03): : 255 - 301
  • [10] CLEAR CELL ONCOCYTOMA OF SALIVARY-GLAND
    ELLIS, GL
    [J]. HUMAN PATHOLOGY, 1988, 19 (07) : 862 - 867